Lisa Stelly Osbourne filed the documents in Los Angeles on Friday citing irreconcilable differences. She listed the date of separation as May 4.
Jack and Lisa have three children together: six-year-old Pearl Clementine, two-year-old Andy Rose and three-month-old Minnie Theodora.
Lisa is asking for joint legal and physical custody of their children. She is also requesting spousal support.
Jack and Lisa married in 2012 and experienced a late-term miscarriage in 2013. The couple have faced other hurdles, including Jack‘s multiple sclerosis diagnosis.
Before getting engaged, Jack and Lisa had been dating for only four months, according to Britain’s Daily Mail.